A high 10% concentration of this vitamin is supported in the formula by zinc salt of pyrrolidone carboxylic acid to balance visible aspects of sebum activity. 8000 mg of ascorbic acid divided into 2-3 doses/day with food and 50 mg of zinc gluconate to be taken daily at bedtime. Johansson U, Akesson B. Interaction between ascorbic acid and acetylsalicylic acid and their effects on nutritional status in man. However, these effects have not consistently translated to clinical outcome benefits in patients with hyper-inflammatory diseases,10 and N-acetylcysteine is not routinely used as an anti-inflammatory or antioxidant in clinical practice. The formula contains a clinically effective combination of Vitamin C, zinc and hyaluronic acid with the additional antioxidant protection of curcumin. The statements and opinions expressed in COVID-19 Curbside Consults are based on experience and the available literature as of the date posted. As a result, ascorbic acid protects against oxidative stress and premature cell aging. It is the imbalance between production of reactive oxygen and nitrogen species and the antioxidant pool in the body that perpetuates further damage and, with a hyperinflammatory response, may contribute to severe manifestations of COVID-19. These include: helping to protect cells and keeping them healthy; maintaining healthy skin, blood vessels, bones and cartilage; helping with wound healing; Lack of vitamin C can lead to scurvy. Listing a study does not mean it has been evaluated by the U.S. Federal Government. After systemic administration, N-acetylcysteine is rapidly converted to cysteine, which is a precursor to glutathione, leading to significant increases in plasma and alveolar glutathione concentrations. Information provided by (Responsible Party): The purpose of this study is to examine the impact of ascorbic acid (vitamin c) and zinc gluconate in reducing duration of symptoms in patients diagnosed with coronavirus disease 2019 (COVID-19). Mar-Apr 2010;38(2):386-414. doi: 10.1177/147323001003800203. For general information, Learn About Clinical Studies. The number of days required to reach a score of 0 from the symptom category of fatigue based on a 0-3 scale: 1=mild fatigue, 2=moderate fatigue, 3=severe fatigue. Ascorbic acid, zinc, vitamin D, and N-acetylcysteine have biologic plausibility for the prevention and treatment of COVID-19 and are candidates for clinical trials evaluating patients with these indications. Differences in number of patients in study arms who experienced side effects from the supplements. 60 natural orange flavour chewable tablets Vita Bubs ™ Vitamin C & Zinc is a premium formulation that helps improve immune system function and supports general health and wellbeing in children. We aim to see whether ascorbic acid and zinc gluconate which has limited side effect profile and is readily available over the counter can decrease the duration of symptoms seen in patients with new diagnosis of COVID-2019. All rights reserved. Zinc is known to be important for immune function and has a role in antibody and white blood cell production. Please remove one or more studies before adding more. A secondary purpose is to see whether Zinc and/or Ascorbic acid supplementation can prevent progression of the severe manifestations of the disease including development of dyspnea and acute respiratory distress syndrome which may require … Sodium ascorbate still consists of ascorbic acid. Because it is necessary for … Each patient will have a composite score ranging from 0-36/day, The number of days required to reach a score of 0 from the symptom category of fever based on a 0-3 scale: 0 = ≤98.6, 1 = >98.6- 100.6, 2 = > 100.6 - 102.6, 3 = >102.6, The number of days required to reach a score of 0 from the symptom category of cough based on a 0-3 scale: 0 = no cough, 1 = mild, 2 = moderate, 3 = severe, The number of days required to reach a score of 0 from the symptom category of shortness of breath based on a 0-3 scale: 0 = no shortness of breath, 1 = with moderate intensity exercise 2 = with walking on flat surface 3 = short of breath with getting dressed or daily activities. Don’t let cold & flu get in the way of your day. Glutathione is an endogenous antioxidant that is frequently depleted in patients with oxidative stress or systemic inflammation, including those with chronic obstructive pulmonary disease and acute respiratory distress syndrome. The information provided is for educational purposes only. Other Questions Vitamin C, also known as ascorbic acid, is an essential nutrient that keeps the body functioning.  (Clinical Trial). We’ve designed this serum to assist in new collagen production and have a lightening effect on epidermal pigmentation. When ascorbic acid (Vitamin C) is chelated with minerals such as Calcium or Magnesium, the minerals help neutralize the acidic properties of ascorbic acid through chelation, and … It is a prescription medicine. Register once and log in for full access to articles and content. Moreover, in vitro and in vivo studies in avians have shown that vitamin C could be protective against avian coronavirus infection, and human trials have found that vitamin C may decrease susceptibility to viral respiratory infections and pneumonia.2 High doses of ascorbic acid reduce the severity and duration of symptoms from the common cold, which is caused by rhinovirus.3 Studies of vitamin C for the treatment of hospitalized and critically ill patients have shown mixed results on mortality, length of stay in the intensive care unit, and duration of mechanical ventilation.4 However, high doses of intravenous vitamin C were generally safe. Product Description Ascorbic Acid & Zinc chewable Tablets is used to prevent or treat low levels of vitamin C in people who do not get enough of the vitamin from their diets. Ascorbic Acid Tablet is used for the short-term treatment of lack of vitamin C (scurvy) in adult and children aged five months and older for whom oral use is not possible, should not be used, or insufficient. Three drops (0.5 mL) of each formulation were applied daily over the randomly assigned hemifaces for 3 months. It’s also readily available as a dietary supplement. Learn about benefits, supplements, deficiency, and more. Active ingredient: ascorbic acid + zinc. Ascorbic acid, also known as vitamin C, is a potent vitamin with various essential bodily functions. Ascorbic acid can prevent cancers by searching and killing free radicals. for 1+3, enter 4. Vitamin C and zinc have many health benefiits, including aiding immunity, reducing the risk of age-related eye diseases and helping wounds heal. The number of days required to reach a score of 0 from the symptom category of headache based on a 0-3 scale: 1=mild headache, 2=moderate headache, 3=severe headache. Patients will then track their symptoms daily from day 0 to day 28 answering 12 basic questions on illness severity.They will stop filling out their daily questions once they reach reach the end of the 28 day study period or at time of hospitalization; whichever comes first . You can select a medicine from this list to find out more - including side effects, age restrictions, food interactions and whether the medicine is subsidised by the government on the pharmaceutical benefits scheme (PBS). Zinc is an essential anti-inflammatory and antioxidant nutrient for many biological processes in humans. Niacinamide (Vitamin B3) is indicated to reduce the appearance of skin blemishes and congestion. Factors such as older age, corticosteroid use, and darker skin are associated with lower concentrations of 25-hydroxyvitamin D, putting these patient populations at higher risk for vitamin D deficiency. Ascorbic acid +zinc consolidates the powers of vitamin C and the miracles of zinc. All other authors report no conflicts of interest to disclose. Study team members will call patients at days 7, 14, 21, and 28 of the study period to assess need for hospitalization, ER visit, or additional medications prescribed by a healthcare provider, and any side effects from the supplements that the patient could have experienced. Standard of care medications only as prescribed by patient's physician. Women of childbearing potential who do not meet the above criteria, last menstrual period greater than 30 days and have a positive pregnancy test. Seth R. Bauer reports that he is a consultant for Wolters Kluwer. A secondary purpose is to see whether Zinc and/or Ascorbic acid supplementation can prevent progression of the severe manifestations of the disease including development of dyspnea and acute respiratory distress syndrome which may require hospitalization, mechanical ventilation, and or lead to death. Patients above the age of 18 who present to the Cleveland Clinic outpatient testing and receive a positive test for COVID-19 will be invited to participate. Because of their potential to influence immune response and reactive oxygen and nitrogen species, and because of their availability as over-the-counter medications, ascorbic acid (vitamin C), zinc, vitamin D, and N-acetylcysteine have been hypothesized to be useful for prevention or treatment of COVID-19. Vitamin D is found in foods such as dairy products, cereals, and oily fish, and is converted to its biologically active form 25-hydroxyvitamin D in the skin through the effect of ultraviolet B radiation on 7-dehydrocholesterol. Copyright © 2020 The Cleveland Clinic Foundation. It is the only brand made with ZincPlus ® Technology that ensures the stable combination of these 2 ingredients so that kids get the full dose they need. Found in foods and dietary supplements, it aids in many biological functions, including the synthesis of collagen, the healing of wounds, and the repair and maintenance of cartilage, bones, and teeth. Patients will then be randomized to one of 4 study arms. Solve this simple math problem and enter the result. Vitamin C, also known as ascorbic acid, has several important functions. Why Should I Register and Submit Results? While we try to regularly update this content, any offered recommendations cannot be substituted for the clinical judgment of clinicians caring for individual patients. Deficiency of zinc increases pro-inflammatory cytokine (IL-1, IL-6, and TNF alpha) concentrations and decreases the production of antibodies, while zinc supplementation has been shown to increase the ability of polymorphonuclear cells to fight infection.2 Zinc has also been implicated in coronavirus biology, with increasing intracellular concentrations of zinc demonstrated to inhibit virus RNA polymerase activity and viral replication in an in vitro and cell culture model of severe acute respiratory syndrome coronavirus 1 (SARS-CoV-1).5 In a meta-analysis evaluating studies comparing zinc supplementation and placebo, high-dose zinc reduced the duration but not the severity of symptoms of the common cold.6 Overall adverse effects and specifically nausea were significantly more frequent with zinc (which may have been dose-dependent), and the effect of prophylactic zinc supplementation was inconclusive. Copyright © 2020 The Cleveland Clinic Foundation. If you are using a mobile device, click on the settings icon to access the Register link. View abstract. Zinc only 2. Click “Register” in the upper right corner and follow the simple instructions to create a new account. E.g. History of Calcium Oxalate kidney stones. A number of randomized trials have evaluated the effect of vitamin D supplementation for the prevention of acute respiratory infections. The authors outline the biologic plausibility, applicable clinical data, and potential role of each of these agents. These formulations were matched for color, feel, and pH. Ascorbic acid, zinc, vitamin D, and N-acetylcysteine have biologic plausibility for the prevention and treatment of COVID-19 and are candidates for clini-cal trials evaluating patients with these indications. Addition of Sodium. The number of days required to reach a score of 0 from the symptom category of new loss of smell based on a 0-3 scale: 1=mild loss of smell, 2=moderate loss of smell, 3=severe loss of smell. May reduce blood uric acid levels and help prevent gout attacks. Patients in arms A, B and C will take study supplements daily for 10 days. To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor. We do not capture any email address. The medicines below all contain the following active ingredient(s): ascorbic acid + zinc. Vitamin D deficiency has been associated with a higher incidence of acute respiratory infections, with a hypothesized link between the seasonality of influenza and vitamin D deficiency. Patients in Arm A (n=130) will receive vitamin C (to be taken divided over 2-3 times a day with meals), patients in Arm B (n=130) will receive zinc gluconate to be taken at bedtime, patients in Arm C (n=130) will receive both vitamin C (to be taken divided over 2-3 times a day with meals) and zinc gluconate (taken at bedtime). Readily available prescribed medications/ supplements- None study supplements, Other Name: Standard prescribed medications/ supplements, Number of days to reach a 50 percent reduction in the cumulative 0-36 symptom score with each symptom evaluated on a 0-3 scale. The impact of vitamin C for the treatment of patients with COVID-19 is unclear, and new clinical trials are under way in China and the United States. Ascorbic acid is essential to your body's ability to take in and process iron. Get the latest research information from NIH: You have reached the maximum number of saved studies (100). However, several agents intended to supplement dietary intake or endogenous molecules may have a theoretical role in preventing or treating the disease. Several agents intended to supplement dietary intake or endogenous molecules may have a theoretical role in preventing or treating COVID-19. Positive pregnancy test (women of child bearing potential who have not had previous sterilization as defined as hysterectomy or tubal ligation). Talk with your doctor and family members or friends about deciding to join a study. All patients who agree to participate in the study will answer a baseline questionnaire about their symptoms at the time of inclusion. Swisse Ultiboost High Strength Vitamin C + Zinc Powder is a premium quality formula designed to provide everyday support for maintaining a healthy immune system, as well as, relief from common cold symptoms when you’re caught off-guard. By blending ascorbic acid with non-acidic forms of vitamin C, the formula is buffered to be gentler on the stomach than ascorbic acid alone. Vitamin C: roles and benefits in the body Antioxidant. Standard of care. The number of days required to reach a score of 0 from the symptom category of diarrhea on a 0-3 scale: 1=mild diarrhea, 2=moderate diarrhea, 3=severe diarrhea. The number of days required to reach a score of 0 from the symptom category of new loss of taste based on a 0-3 scale: 1=mild loss of taste, 2=moderate loss of taste, 3=severe loss of taste. Advanced liver disease awaiting transplant. Fusion Vitamin C 1000 Advanced also contains zinc glycinate, a form of zinc that’s more readily available to the body than some other forms of zinc, such as zinc sulfate. Vitamin C, also known as ascorbic acid, is a vitamin found in many common foods like citrus fruits, apples, berries, potatoes and peppers. Keywords provided by Milind Desai, The Cleveland Clinic: Dietary Supplement: Ascorbic Acid and Zinc Gluconate. The primary composition of the active and vehicle serums in this study included L-ascorbic acid, tyrosine, and zinc (active); and bioflavinoid, hyaluronic acid, and water base (vehicle), respectively. to ascorbic acid (vitamin C) 500mg: Total ascorbic acid (vitamin C) 1000mg: Pyridoxine hydrochloride : 60.8mg : equiv. 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